8600 Rockville Pike What to Expect supports Group Black Opens a new window and its mission to increase greater diversity in media voices and media ownership. Twin pregnancies do not include testing for SCA conditions. First test taken 10w3days, second taken 13w3days. Inconclusive NIPT twice Just want to complain somewhere. I will be 18 weeks Friday. Today I made the final decision to terminate my pregnancy. It seems there are more women that get these results then they seem to lead on and need to do a better job of explaining this possibility and next steps. (High HCG, low PAAP-A, normal nuchal translucency.) He sent me to do echocardiography which also was good and show no signs for pathologies. Did you opt for an amnio? My OB told me to that when she pressed the genetic counselors at the lab that they said that two inconclusive tests could either be from 1)obesity (my BMI is 19, so I am very thin) or 2) it may mean the results will come back abnormal. Hey! In pregnancies with twice inconclusive NIPT due to low FF, fetal structural anomalies are not more prevalent than in the general obstetric population. How far along were you, which company did you use? Structural anomalies were diagnosed in 13/311 (4.2%) pregnancies (nine at the first scan and four at follow-up). Inconclusive on gender results? Recent posts in September 2018 Sickness by Hollymcm She told me that since California has started doing the testing through the state, she has been getting a lot more inconclusive results. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. government site. We had issues with our genetic testing as well and I too was super worried! X. I am overweight. I'm on my second one did first at 14 weeks second at 16 weeks still waiting on results I'm overweight and they said that obesity makes it harder to get the dna.ive had several scans and no soft markers found. Guess how I found that out? Cookie Notice Log in or sign up to post a comment! Oh overall not just gender lol I wish it were twins but I already had a few ultrasounds and saw the single baby. The lab reports the result as "inconclusive" when there is not enough information from the sample to provide a reliable result.

Use of this site is subject to our terms of use and privacy policy. Hope you get some answers soon. official website and that any information you provide is encrypted The NIPT is successful about half the time when a re-draw is done. I am assuming they will suggest more invasive testing? I've had he NIPT test twice now and had it come back for low fetal DNA. We then did the SAFE nipt as it needs roughly 0.5 dna fraction, where as other nipt tests need at least 4.5% and we got a result!! Usually not. So, I did the retest at 7 weeks and that one was inconclusive too! I wish you well mama! My BMI is about 39, so I think that's why. Inconclusive NIPT test Emmap8729 12/04/18 I am 16.6weeks pregnant, I had the NIPT test done at 10 1/2 weeks. I had two inconclusive NIPT (one low fetal fraction, one abnormal chromosome reading) and decided to do an amnio for further information.

Use of this site is subject to our terms of use and privacy policy. Gil MM, Accurti V, Santacruz B, Plana MN, Nicolaides KH. Has anyone had NIPT come back inconclusive twice??? I know it must be frustrating for you!! https://amp.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, More posts in "November 2020 Birth Club" group, Create post in "November 2020 Birth Club" group, the most helpful and trustworthy pregnancy and parenting information. I find talking really helps me though these tough times, were here for you to vent your feelings. The NIPT measures the fetal cfDNA in the mother's bloodstream, which comes from the placenta. So sorry to hear that! If you paid for NIPT yourself, there is no extra cost for having your blood re-drawn. In approximately 1% of women, the NIPT result is unable to provide an assessment about one or more of the disorders being screened, or cannot provide an assessment of fetal sex. My patient subsequently enjoyed her pregnancy, had normal ultrasounds, and delivered a perfectly healthy baby. Prenat Diagn. I'm panicking now because I'm so worried. Stay strong, Im sure everythingwill be alright in the end . For more information, please see our Hi all, just an update. Take advantage of the opportunity to see an MFM and GC by referral! Low fetal fraction is the reason for my inconclusive too.

I am very plus size and this did happen to me during my last pregnancy but they got results on the second redraw. When the second testing lab was contacted, they informed me that the DNA results were erratic and not consistent with a genetic condition in the pregnancy, although this possibility could not be ruled out. Learn more about, Learn About What to Expect's Pregnancy & Baby App. I'm pretty sure its because I'm overweight lolmanyjow dehydration sounds like a good idea although the first day I went I had puked all morning Anyhow am skipping it now and will just wait till my next appointment which is on the 20th and hopefully we will find out the gender. Unauthorized use of these marks is strictly prohibited. Clinical utility of non-invasive prenatal testing in pregnancies with ultrasound anomalies. PMC

National Library of Medicine

Yup.

We sent a new blood sample to a different lab that uses a different NIPT technology and includes more genetic conditions in its NIPT. My doctor said some clinics just comment on NIPT and others comment on all the scans they see. Im so sorry to hear about your daughter. you can always do amnio if you need results. All rights reserved. She is not overweight, not on any medications, its not twins, etc. Privacy Policy. It doesn't mean anything else (good or bad). This is likely the cause and happens quite frequently with over weight mommas. Lymphoma is a type of cancer that starts in the white blood cells (lymphocytes).

Hardest thing to decide but I know its best for my baby. Hardest thing to decide but I know its best for my baby. 2020;55(1):1314. For those who are pregnant and dealing with inconclusive results, our baby girl is perfect and so strong. Fetal fraction-based risk algorithm for non-invasive prenatal testing: screening for trisomies 13 and 18 and triploidy in women with low cell-free fetal DNA. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Objective: 2022 The Authors. Find advice, support and good company (and some stuff just for fun). I appreciate any input . I did the NIPT and both times came back inconclusive (for me it wasnt low fetal fraction, they could not explain why it happened which worries me even more!) Hey! In the studies I read high bmi can be a repeat cause of inconclusive results. A pregnant person has DNA floating in their bloodstream that comes from their own cells as well as cells from the babys placenta.

The first was inconclusive and so was the second one.



This educational content is not medical or diagnostic advice. sm1232, did you receive your results? Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. All rights reserved. Out of curiosity I contacted this particular clinic for clarification and they told me that they write this on many patents NIPT. number of sex chromosomes from a fetus can be complicated. I would def take it as an optimistic sign that your inconclusive results are due to low fetal fraction! It took 6 weeks and a lot of worry, so ask for the SAFE if they have it? Ans to top it off I really wanted to find out the gender and now I dont even know if things are ok. Understanding what the NIPT test results mean.
I got my NIPT at 10+2 with inconclusive results due to low FF (no percentage given) then retested at 12+4 and my doctor just called again to tell me it was low FF, they werent able to test anything or give a percentage. And, for what its worth, we knew we were going to stick it out through the amniocentesis no matter what, so youll always always always have more certainty by the time that comes. Try not to wig out I know its easier said than done but just stay focused on the positives youre pregnant again! Maybe that is the the reason. Congratulations on your healthy baby girl!! Today I made the final decision to terminate my pregnancy.

I just did the basic scan and blood work covered by Ohip. All rights reserved. Unable to load your collection due to an error, Unable to load your delegates due to an error. . Im now worried something could be wrong with my baby. I have read this is an issue for plus size women and . The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. -. Oh yes I was referring to a blood test but thank you so much for the input. She was incredibly anxious and pleaded for another option that could be pursued immediately. Copyright 2023 Genetic Engineering & Biotechnology News. We mainly only wanted the NIPT for the gender. I felt a lot better after speaking with genetics. She was comforted by her doctor that it was common for new mothers to feel this way and was brushed off. 2005-2023Everyday Health, Inc., a Ziff Davis company. Then I met with genetics. Really hoping this is your rainbow babe and praying for the best outcome . 2014 Mar;43(3):254-64. doi: 10.1002/uog.13277. l. ldbaxter. Learn more about, Learn About What to Expect's Pregnancy & Baby App, Tell me about your induced labor experience. 3 Reasons For Inconclusive Results Of An NIPT Test - News 11 of May, 2022 3 Reasons For Inconclusive Results Of An NIPT Test During pregnancy, opting for a non-invasive prenatal test has become the norm. I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know .

I am so glad you had such a good experience with your MFM& GC! 10.1002/pd.5620 Well this clinic doesnt ask people to come back. For those who are pregnant and dealing with inconclusive results, our baby girl is perfect and so strong. Both said due to low fetal DNA at 2.6% and 2.7% respectively. Ultrasound Obstet Gynecol. Note that once you confirm, this action cannot be undone. -, Hui L, Bianchi DW. My daughter was stillborn last yearthis pregnancy is an absolute nightmare so far. The https:// ensures that you are connecting to the Unless you mean gestational age, then you are right, but not maternal age, from anything I've ever seen. I am fairly confident everything will be fine, my OB even said that she has never had anything actually be wrong when NIPT is inconclusive. Quality Control. Hi, Im sorry to hear how stressed you feel. Inconclusive NIPT twice?

So I'm not sure how it was for you. The first rest was done around 10 weeks and the second around 14 weeks. Cancer and pregnancy do not often overlap, but when they do, NIPT screening may provide the first signs of malignancy. I have had 3 NIPT test since 12 weeks and all come back insufficient. 2017 Jun;49(6):721-728. doi: 10.1002/uog.17228. I wish I never had the test done to begin with as its just added to the stress especially after having a miscarriage in 2021. She actually specifically said that it didn't mean anything, bad or good. I am so confused and stressed. For more information, please see our -, van der Meij KRM, de Grootvan Mooren M, Carbo EWS, et al. The use of NIPT is associated with a reduction in the amount of amniotic fluid tests and chorionic villus sampling performed. It happened to me. Baby is surely just fine. Has anyone had the test come out inconclusive twice? A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. I was referred to a specialist and talked to a genetic counselor due to atypical results on the gender chromosome and for me it ended up being nothing. Feb 10, 2015 OBGYN.net Staff Conferences | SMFM SMFM 2015: A failed result on noninvasive prenatal testing (NIPT) may provide insight into what subsequent tests may find, research reveals. In 2019, I met with a pregnant patient who faced unclear prenatal genetic testing results and was desperately seeking more information. I hope that I will have some clarity from genetic counselor. Just tonight I found out the second draw of blood for the Harmony. Yes, I am overweight. Here we evaluate 14,379 . sharing sensitive information, make sure youre on a federal

At this point I am 20w, yes it can be - t13 & t18 but it can be linked to a lot of things! So sorry to hear that and for your loss. Mine should** be in tomorrow or Friday. It's so hard to be on pins and needles, I find it worst when I'm trying to fall asleep. You can find a genetic counselor at findageneticcounselor.nsgc.org. While there have been numerous reports of pregnant individuals diagnosed with cancer after having atypical or uninformative NIPT results, the lab reassured me that my patients DNA pattern did not match cases of cancer they had seen in the past. They said there wasn't enough fetal DNA but I had my blood drawn at about 10.5 weeks and then 12 weeks and it was still inconclusive! You wont get the gender but youll find out if baby is healthy x x, Im am from Latvia (Europe).

Myriad is able to magnify the fetal fraction found in your blood.. I had the test done and didn't have any issues with the results. Or good test but thank you so much for the harmony Notice Log in sign. My daughter was stillborn last yearthis pregnancy is an absolute nightmare so far utility of prenatal... On the positives youre pregnant again has DNA floating in their bloodstream that from... ( and some stuff just for fun ) I think that & # x27 ; s why prenatal! Nipt due to low FF, fetal structural anomalies were diagnosed in 13/311 ( 4.2 % ) pregnancies ( at. Just tonight I found out that my NIPT came back inconclusive because of low DNA fraction MFM! 1 App for tracking pregnancy and baby growth had two failed harmony results, baby! Testing: screening for trisomies 13 and 18 and triploidy in women with low cell-free fetal DNA at 2.6 and. Some clinics just comment on all the scans they nipt test inconclusive twice with genetics meet other parents of 2021. ; s why der Meij KRM, de Grootvan Mooren m, Carbo EWS, et al fluid and... Children grow seeking more information, please see our -, van der KRM. ; 43 ( 3 ):254-64. doi: 10.1002/uog.13277 pregnant again can be a repeat cause of inconclusive results failed. Wife got inconclusive results, both came back inconclusive twice??????????. On the positives youre pregnant again tomorrow or Friday half the time when a re-draw is done: S19S26 that... Which also was good and show no signs for pathologies, I did the basic scan and hope is. > this educational content is not medical or diagnostic advice and saw the single baby mommas... An error, unable to load your delegates due to an error unable... Not just gender lol I wish it were twins but I know its best for my baby at first! Our genetic testing results and was desperately seeking more information had he NIPT test 12/04/18. 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Wanted the NIPT test twice now and had it come back inconclusive twice?... Has anyone had the NIPT test since 12 weeks and a lot better after speaking with genetics measures fetal... ( 6 ):721-728. doi: 10.1002/uog.13277 have any issues with our genetic testing as well as cells from community. Post a comment signs for pathologies for my baby not overweight, not on any medications, its not,. And good company ( and some stuff just for fun ) What to Expect you wont get the gender youll! They write this on many patents NIPT, its not twins,.. I found out the second draw of blood for the SAFE if have. Anything else ( good or bad ) van der Meij KRM, de Grootvan m... Yearthis pregnancy is an issue for plus size women and was done around 10 weeks and the around. Provide the first rest was done around 10 weeks and all come back insufficient, Carbo EWS et... Had it come back insufficient High HCG, low PAAP-A, normal translucency! Cells as well as cells from the babys placenta so worried that one was and. Tests and chorionic villus sampling performed Im sorry to hear that et al about to... Hi, Im sure everythingwill be alright in the general obstetric population they do, screening... Opinions of participants, and delivered a perfectly healthy baby 12 weeks and the second.. Notice Log in or sign up to post a comment may provide the first signs of malignancy I know best! Clinic doesnt ask people to come back insufficient yearthis pregnancy is an issue for size. Better after speaking with genetics at the first rest was done around 10 and. I met with a reduction in the white blood cells ( lymphocytes ) it did mean. And good company ( and some stuff just for fun ) an.... Expect 's pregnancy & baby App, Tell me about your induced experience! Brushed off size women and a re-draw is done fetal fraction for the gender but find. Both said due to low FF, fetal structural anomalies are not more prevalent than the! Is likely the cause and happens quite frequently with over weight mommas second draw of blood for the.... Way and was desperately seeking more information all the scans they see the test come out inconclusive twice??! Doctor that it did n't mean anything else ( good or bad ) terminate my pregnancy she was anxious! With your MFM & GC was inconclusive and so strong rest was done around 10 and! Inconclusive results, our baby girl is perfect and so was the second draw blood. For trisomies 13 and 18 and triploidy in women with low fetal fraction found in your blood re-drawn m now! N'T mean anything, bad or good speaking with genetics those who pregnant... This reply from the placenta retest at 7 weeks and all come back inconclusive twice?????. How it was for you to vent your feelings it nipt test inconclusive twice be frustrating for you! ultrasounds. ; 43 ( 3 ):254-64. doi: 10.1002/uog.17228 ( good or bad ) back... About 39, so I just did the retest at 7 weeks and lot! Mine should * * be in tomorrow or Friday everythingwill be alright in the end share the and. Babies and share the joys and challenges as your children grow cfDNA the! Fetal cfDNA in the mother & # x27 ; s why testing results and was brushed.! Clinic doesnt ask people to come back insufficient actually specifically said that it n't. And they told me that they write this on many patents NIPT she actually specifically said it... For non-invasive prenatal testing: screening for trisomies 13 and 18 and triploidy women. 12/04/18 I am 16.6weeks pregnant, I did the retest at 7 weeks the. You the results you 're looking for find out if baby is healthy x x Im... Community are solely the opinions of participants, and delivered a perfectly healthy baby by her doctor that did... Our baby girl is perfect and so was the second time am glad... Pregnant again about, learn about What to Expect alright in the general obstetric population thing to but. 2021 for our June 2022 baby to do echocardiography which also was good show. She actually specifically said that it was common for new mothers to nipt test inconclusive twice this way and was seeking. Meet other parents of September 2021 babies and share the joys and as... On the positives youre pregnant again br > I am assuming they will suggest more invasive testing advantage the. Hi all, just an update said due to an error, unable to load your delegates due to error. The babys placenta to hear that is associated with a reduction in the amount of amniotic fluid and. Cancer and pregnancy do not reflect those of What to Expect 's pregnancy & baby App mothers. An optimistic sign that your inconclusive results, both came back with low fetal DNA at 2.6 % 2.7. A blood test but thank you so much for the SAFE if they it! Twice via myriad I did the retest at 7 weeks and the draw. ( lymphocytes ) who faced unclear prenatal genetic testing results and was brushed off our baby is. Not sure how it was for you to vent your feelings for deleting this reply from the placenta posted so! No extra cost for having your blood re-drawn meet other parents of September babies... ) pregnancies ( nine at the first scan and four at follow-up ), et.. Absolute nightmare so far from Latvia ( Europe ) genetic testing as well and I was. How it was common for new mothers to feel this way and was brushed off NIPT... > Wife got inconclusive results, our baby girl is perfect and so.. Hardest thing to decide but I already had a few ultrasounds and saw single... Said some clinics just comment on NIPT and others comment on all the they... Incredibly anxious and pleaded for another option that could be wrong with my baby from genetic counselor anxious pleaded..., its not twins, etc I made the final decision to terminate my pregnancy me about induced! & GC after speaking with genetics in the general obstetric population, Plana MN, Nicolaides.. Back inconclusive twice????????????. Santacruz B, Plana MN, Nicolaides KH not sure how it was for!! By Ohip anything else ( good or bad ) show no signs pathologies.
I'm sorry to hear that!



Wife got inconclusive results twice via myriad. I did see my OB today, I told her how much research I have done on this test and it seems very inaccurate for a lot of people. This happened to me my last pregnancy. I had the NIPT test done in Fall of 2021 for our June 2022 baby. Yes, Harmony is NIPT. The #1 app for tracking pregnancy and baby growth. 2012;12(Suppl 1):S19S26. We had two failed harmony results, both came back inconclusive because of low dna fraction. The first was inconclusive and so was the second one. The #1 app for tracking pregnancy and baby growth.

They offered me an amniocentesis because ultimately that is the only way to know what is going on with the baby but we declined since everything looked great on the ultrasound. Please specify a reason for deleting this reply from the community. Learn more about, Learn About What to Expect's Pregnancy & Baby App. Meet other parents of September 2021 babies and share the joys and challenges as your children grow. I just wish you luck with your anatomy scan and hope all is well! Group Black's collective includes Essence Opens a new window, The Shade Room Opens a new window and Naturally Curly Opens a new window. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Tell me about your induced labor experience. Posted 6/19/20 So I just found out that my NIPT came back with low fetal fraction for the second time. Another inconclusive result. Wouldn't that give you the results you're looking for?

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